Localization of cytochrome P1-450 and P3-450 genes to mouse chromosome 9.
نویسندگان
چکیده
منابع مشابه
cDNA and complete amino acid sequence of mouse P2(450): allelic variant of mouse P3(450) gene.
From a Xgt11 cDNA library derived from isosafrole-treated DBA/2N mouse liver (1), the longest cDNA insert was sequenced by the dideoxy method. Over a range of 1,847 bp, the nucleotide sequence of P2450 is identical to that of P345O cDNA from C5YBL/6N mice (2) except for three isolated changes: C—»G transversion at position 1211, T—J>G transversion at position 1648, and T deleted at position 167...
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We expressed mouse cytochrome P1-450 and P3-450 using recombinant vaccinia virus gene expression system in HeLa cells that were devoid of significant basal levels of P-450. HeLa cells were infected with the recombinant vaccinia virus containing either mouse cytochrome P1-450 or P3-450 cDNA, and the cell lysates were analyzed for the kinetics of P-450 enzyme activity and protein expression at th...
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The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450 gene family (P1-450 and P3-450 in the C57BL/6N mouse) has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster X mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450 and P3-450 full-length...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1984
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.81.10.3163